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Description
PRMT5 Recombinant Rabbit mAb (S-2336-126)Product Specification Host Rabbit Antigen PRMT5 Synonyms Protein arginine N methyltransferase 5; 72 kDa ICln binding protein; Histone arginine N methyltransferase PRMT5; Jak binding protein 1; Shk1 kinase binding protein 1 homolog (SKB1 homolog; SKB1Hs); HRMT1L5; IBP72; JBP1; SKB1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession O14744 Clone Number S 2336 126 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC
Product Specification
| Host | Rabbit |
| Antigen | PRMT5 |
| Synonyms | Protein arginine N-methyltransferase 5; 72 kDa ICln-binding protein; Histone-arginine N-methyltransferase PRMT5; Jak-binding protein 1; Shk1 kinase-binding protein 1 homolog (SKB1 homolog; SKB1Hs); HRMT1L5; IBP72; JBP1; SKB1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | O14744 |
| Clone Number | S-2336-126 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms |
| Positive Sample | HeLa, HEK-293, HepG2, C2C12 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
PRMT5 (protein arginine methyltransferase 5) is an evolutionarily conserved type II methyltransferase that catalyzes the symmetric dimethylation of arginine residues (SDMA) on histones H3R8me2s and H4R3me2s and on a broad spectrum of non-histone substrates including Sm proteins, RNA-binding proteins and transcription factors, thereby orchestrating chromatin remodeling, spliceosome assembly, transcriptional repression, signal transduction and stem-cell pluripotency; it functions as a tetrameric complex with MEP50, localizes to both cytoplasm and nucleus, exhibits oncogenic addiction in cancers such as mantle cell lymphoma and glioblastoma through its control of methionine and serine metabolism, and is targeted by potent, selective small-molecule inhibitors currently in clinical trials for tumors harboring MTAP deletions.
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