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Description
CYP3A4 Recombinant Rabbit mAb (S-2281-2)Product Specification Host Rabbit Antigen CYP3A4 Synonyms Cytochrome P450 3A4; 1,4 cineole 2 exo monooxygenase; 1,8 cineole 2 exo monooxygenase; Albendazole monooxygenase (sulfoxide forming); Albendazole sulfoxidase; CYPIIIA3; CYP3A3 Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession P08684 Clone Number S 2281 2 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms Positive Sample mouse liver Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | CYP3A4 |
| Synonyms | Cytochrome P450 3A4; 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; Albendazole monooxygenase (sulfoxide-forming); Albendazole sulfoxidase; CYPIIIA3; CYP3A3 |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | P08684 |
| Clone Number | S-2281-2 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms |
| Positive Sample | mouse liver |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Ms |
Background
CYP3A4 is a 57-kDa cytochrome P450 mono-oxygenase anchored in the endoplasmic reticulum of human liver and intestine, where its large, highly lipophilic active site binds a broad spectrum of substrates—including more than half of all marketed drugs—catalyzing the insertion of an oxygen atom into C–H or C=C bonds to increase polarity and facilitate elimination; expression is up-regulated by nuclear receptor PXR and down-regulated by inflammatory cytokines, leading to up to 40-fold inter-individual variability, and common genetic variants (e.g., *22) modestly alter activity, while potent inhibitors like ketoconazole or grapefruit furanocoumarins and inducers like rifampicin or St. John’s wort can precipitate clinical drug–drug interactions, making CYP3A4 a central determinant of systemic exposure, efficacy, and toxicity for statins, calcium-channel blockers, immunosuppressants, and many oncology agents.
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4.5 ★★★★★
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Product Reviews
★★★★★ 5
Family Drama!
Format: Spiral-bound
This authors whole series is worth looking into. I did buy a few and passed them onto my sister’s family hoping it will bring them more together. I have heard back from one of them that they are working together on the flip chart. I have learned that there can be one person in the family that is the peace-maker:)
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Reviewed in the United States on June 20, 2024
★★★★★ 5
This book transformed my life in a way that other books haven't
Format: Paperback
This book transformed my life. It took me a full year to read (I did read several other books within the same timeframe), I read the first section of it with my work team, did all of the homework or suggested activities within, attended some seminars by the Canfield Training Group, and lastly invested in becoming a trainer of the curriculum because I connected so well with the concepts presented.
I have been teaching leadership principles within a university setting for almost 20 years. This book adds to that knowledge, as well as brings about several exercises to shift from unconscious to conscious brain activity that I really needed in my life for my own progression. I plan to read this book annually, as it has so much information in it that it is worthy of additional time and study. I had my first copy cut and spiral bound so that I can spend more time on individual pages, treating the book more like a manual. I often find myself referencing the book and have shared much of it's teachings in all arenas of my life.
In my library of hundreds of business books, this one has been placed onto my top 5 list. I am so grateful for all it has done to increase my productivity, improve my relationships, accomplish more with less, change my paradigms about asking for what I need, spur me to take a much stronger conscious approach to money management, and the list goes on.
I would highly recommend this book to anyone who is open to learning, open to diving deep into oneself, and anyone who is willing to take complete responsibility for one's own life, one's own success, and one's own ability to let go of the past to rewrite a new future. This book has very practical, easy to carry out activities and projects to radically improve one's life.
Lastly, I recommend reading this book with others who you can share your progress with. Coming together in our work team to read and discuss was so helpful as we shared our a-ha moments, our lists, our completed assignments like our have's, do's and be's list and goal binder. We had a vision board party where we each created ours and then presented it to each other. Many awesome things started to manifest after putting those boards together, and we could celebrate those things with each other. Reading this book together created a strong bond with that team. As the year progressed our schedules made it more challenging to read it together, so we decided to finish it individually. But we learned that we missed the group learning, so we will soon start up again together as a group with an altered format of presenting the chapters to one another instead of actually reading and discussing together. (We would come together on our lunch hour to read along in our books with the cd of the book, pausing it often to discuss)
Individually, I would listen to the book while commuting for 60 minutes every day. I would then review key things I would hear at night before bed. It was bitter sweet when I finished it last night. I truly did not want the book to end, yet I was so excited to check off a goal of completing the book by Nov 1st. This book truly has made a significant positive impact on my life. It was well worth my time and money.
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Reviewed in the United States on October 29, 2016
★★★★★ 5
Great book-empowering
Format: Paperback
I bought to have as a reference. I listen to the audio book….been through it 4 times! So much empowering info. I never read a book more than once but this is a big exception (other than the Bible of course)😊
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Reviewed in the United States on May 23, 2026
★★★★★ 5
The Success Principles is a must have in any "success" book home library...
Format: Paperback
I read the first version of The Success Principles back in 2009 and I honestly felt like I came across one of the best and most complete resources for success (and really life) I have ever read. I was even more thrilled when I discovered there was The Success Principles for Teens because finding effective ways to teach these life tools and techniques to my daughters has always been a top priority, and challenge. My oldest daughter has not only read it, she has even referred back to some of the principles when I obviously break them :).
I had all but forgotten pre-ordering this updated version of The Success Principles until I got the surprise package in the mail today. All of the core content in this version is still there, but what was exciting to read were the new success stories included of people that bought the original book and had breakthroughs.
The completely new content included is "Success in the Digital Age" and it is a fantastic resource. I would consider myself very knowledgeable when it comes to technology and Internet Marketing (having worked as a Sr. System Engineer for over a decade and years learning and implementing various Internet Marketing solutions), and I can say this addition is fantastic. The content and advice he managed to include in just five chapters is impressive, and spot on. If topics like social media, technology, and online branding are areas that are a weakness, or you want to learn more about the most effective ways to leverage these and other technical solutions used by some of the most successful leaders in this space, than you will love this addition to the book.
I will end this review by saying I am life coach, and resources like these are gold. I am constantly referring back to this text before and after sessions. I am a huge fan of countless self-help experts and bestselling authors, and I have a huge list of books I love and regularly recommend, but none are such a complete resource like this book. As one of the "experts" in this space said about this book, trying to just identify the "big ideas" included in this book is virtually impossible, because everything he includes IS a "big idea." So if you are a fan of this type of content this is a must have in your library, if only for a reference.
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Reviewed in the United States on January 28, 2015
★★★★★ 5
Success Principles is a handbook you definitely want to carry with you.
Format: Kindle, Format: Kindle
Many of us are looking for ways to improve our lives, our relationships, and our business. We read books, take training and hire coaches. And these things work.
Whether you are new in your quest to self improvement, or a seasoned veteran, the Success Principles is one of the “must read” handbooks you want to read, apply and keep at your side. It contains 67 principles described in a concise, simple to understand entertaining way. Each of these principles by itself is certain to bring positive change in different aspects in your life. As a group they are certain to move your life forward.
You will learn how to improve your relationships by listening and asking for feedback. You will learn to focus on those things that truly matter and let go of the good to leave time and resources for the great. You will learn ways to take care of yourself, put yourself in touch with your thoughts and your emotions, and slow your mind down so that you can be creative, concentrate and work more effectively. You will learn ways to communicate with others, to tap into “masterminds”, to ask for what you need, to overcome resistance, obstacles and fears and to move forward.
I am a fan of the Success Principles and Jack Canfield's work. Everything contained in this book is taught in his seminars. Powerful yet simple techniques.
Buy the book. Read it. And then, every few days concentrate on bringing one of the principles into your life. Sit back and enjoy the results.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 29, 2015
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