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Description
RNA polymerase II CTD repeat YSPTSPS (phospho S5) Recombinant Mouse mAb (S-3420)Product Specification Host Mouse Antigen RNA polymerase II CTD repeat YSPTSPS (phospho S5) Synonyms DNA directed RNA polymerase II subunit RPB1; RNA polymerase II subunit B1; 3' 5' exoribonuclease; DNA directed RNA polymerase II subunit A; DNA directed RNA polymerase III largest subunit; RNA directed RNA polymerase II subunit RPB1; POLR2; POLR2A Location Cytoplasm, Nucleus Accession P24928 Clone Number S 3420 Antibody Type Mouse mAb Isotype IgG1
Product Specification
| Host | Mouse |
| Antigen | RNA polymerase II CTD repeat YSPTSPS (phospho S5) |
| Synonyms | DNA-directed RNA polymerase II subunit RPB1; RNA polymerase II subunit B1; 3'-5' exoribonuclease; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase III largest subunit; RNA-directed RNA polymerase II subunit RPB1; POLR2; POLR2A |
| Location | Cytoplasm, Nucleus |
| Accession | P24928 |
| Clone Number | S-3420 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1 |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, 293T, NIH/3T3 |
| Purification | Protein G |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms |
Background
RNA polymerase II CTD repeat YSPTSPS (phospho S5) is a crucial component of the RNA polymerase II complex, specifically referring to the phosphorylated serine 5 residue within the heptapeptide repeat sequence YSPTSPS in the CTD (C-terminal domain) of the largest subunit of RNA polymerase II. This phosphorylation of serine 5 plays a significant role in the transcription process, particularly during the initiation and early elongation phases. It helps in the recruitment of transcription factors and other regulatory proteins, facilitating the assembly of the pre-initiation complex and enabling efficient transcription initiation. Additionally, the phosphorylation status of S5 can influence the interaction of RNA polymerase II with other components of the transcription machinery, thereby regulating gene expression and ensuring proper processing of nascent RNA transcripts.
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