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Description
ALKBH5 Recombinant Rabbit mAb (S-2264-39)Product Specification Host Rabbit Antigen ALKBH5 Synonyms RNA demethylase ALKBH5; Alkylated DNA repair protein alkB homolog 5; Alpha ketoglutarate dependent dioxygenase alkB homolog 5; ABH5; OFOXD1 Immunogen Recombinant Protein Location Nucleus Accession Q6P6C2 Clone Number S 2264 39 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample MCF7, Jurkat, HeLa, HepG2 Purification Protein A Concentration 2 mg ml
Product Specification
| Host | Rabbit |
| Antigen | ALKBH5 |
| Synonyms | RNA demethylase ALKBH5; Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5; ABH5; OFOXD1 |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | Q6P6C2 |
| Clone Number | S-2264-39 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | MCF7, Jurkat, HeLa, HepG2 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:5000 | Hu |
| IHC-P | 1:250 | Hu |
Background
ALKBH5 is a nuclear 45-kDa Fe(II)- and 2-oxoglutarate-dependent dioxygenase that selectively demethylates N6-methyladenosine (m6A) in single-stranded RNA, thereby dynamically modulating mRNA splicing, export, stability, and translation; highly expressed in testes and within nuclear speckles, it is essential for spermatogenesis and fertility, while in somatic tissues it orchestrates glucose and lipid homeostasis through independent regulation of GCGR and mTORC1 signaling, and its dysregulation—via hypoxia-inducible upregulation or cancer-associated overexpression—drives stemness, proliferation, and chemoresistance in breast cancer, glioblastoma, and ovarian cancer by demethylating oncogenic transcripts such as NANOG and FOXM1, positioning ALKBH5 as a central epitranscriptomic hub linking metabolism, reproduction, and malignancy.
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