L-Ergothioneine - 25 mg, 30 capsules - 3 pack
SKU: 77485590828

L-Ergothioneine - 25 mg, 30 capsules - 3 pack

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Description

L-Ergothioneine - 25 mg, 30 capsules - 3 packErgothioneine is a powerful amino acid that helps fight the signs of aging and supports numerous aspects of health. Supports longevity by aiding in telomere length maintenence 1 Combats oxidative stress in the brain to support cognition 2 Protects the heart and is associated with reduced cardiovascular mortality 3 View Certificate of Analysis Research Supported Benefits: Supports Longevity. Research shows that ergothioneine supports longevity by

Ergothioneine is a powerful amino acid that helps fight the signs of aging and supports numerous aspects of health.

  • Supports longevity by aiding in telomere length maintenence 1
  • Combats oxidative stress in the brain to support cognition 2
  • Protects the heart and is associated with reduced cardiovascular mortality 3

View Certificate of Analysis

Research-Supported Benefits:

Supports Longevity. Research shows that ergothioneine supports longevity by protecting against accelerated telomere shortening. (1) Longer telomeres are a powerful predictor of increased lifespan and healthspan. (4)

Maintains Cellular Health. Ergothioneine has been shown to reduce levels of oxidative stress. High levels of oxidative stress may contribute to DNA damage, a decline in ATP (cellular energy) production and elevated inflammatory markers. (5)

Promotes Heart Health. By reducing oxidative stress, ergothioneine exhibits powerful cardioprotective properties. Oxidative stress is associated with accelerated aging of heart cells, studies show ergothioneine reduces cardiac-related mortality risk. (6)

Enhances Brain Health. Low levels of ergothioneine are correlated with neurodegeneration and cognitive impairment. (7) Animal studies have found that administration of ergothioneine improves markers of memory and mood. (8)

Improves Performance. Research suggests ergothioneine may improve markers associated with fitness and muscle health. One study found that administration ergothioneine to mice increased time to exhaustion during aerobic activity and enhanced protein synthesis post-exercise. (9)

References:

1. Samuel P, Tsapekos M, de Pedro N, Liu AG, Casey Lippmeier J, Chen S. Ergothioneine Mitigates Telomere Shortening under Oxidative Stress Conditions. J Diet Suppl. 2022;19(2):212-225. doi:10.1080/19390211.2020.1854919

2. Wijesinghe P, Whitmore CA, Campbell M, et al. Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer's disease. Front Neurosci. 2023;17:1107436. Published 2023 Mar 14. doi:10.3389/fnins.2023.1107436

3. Dare A, Elrashedy AA, Channa ML, Nadar A. Cardioprotective Effects and in-silico Antioxidant Mechanism of L-Ergothioneine in Experimental Type-2 Diabetic Rats. Cardiovasc Hematol Agents Med Chem. 2022;20(2):133-147. doi:10.2174/1871525719666210809122541

4. Heidinger BJ, Blount JD, Boner W, Griffiths K, Metcalfe NB, Monaghan P. Telomere length in early life predicts lifespan. Proc Natl Acad Sci U S A. 2012;109(5):1743-1748. doi:10.1073/pnas.1113306109

5. Fu TT, Shen L. Ergothioneine as a Natural Antioxidant Against Oxidative Stress-Related Diseases. Front Pharmacol. 2022;13:850813. Published 2022 Mar 18. doi:10.3389/fphar.2022.850813

6. Smith E, Ottosson F, Hellstrand S, et al. Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease. Heart. 2020;106(9):691-697. doi:10.1136/heartjnl-2019-315485

7. Wu LY, Kan CN, Cheah IK, et al. Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in an Elderly Cohort Attending Memory Clinics. Antioxidants (Basel). 2022;11(9):1717. Published 2022 Aug 30. doi:10.3390/antiox11091717

8. Ishimoto T, Kato Y. Ergothioneine in the brain. FEBS Lett. 2022;596(10):1290-1298. doi:10.1002/1873-3468.14271

9. Fovet T, Guilhot C, Delobel P, Chopard A, Py G, Brioche T. Ergothioneine Improves Aerobic Performance Without Any Negative Effect on Early Muscle Recovery Signaling in Response to Acute Exercise. Front Physiol. 2022;13:834597. Published 2022 Feb 9. doi:10.3389/fphys.2022.834597

  • Ergothioneine is an amino acid that your body is unable to make on its own but can be obtained from eating foods such as certain types of mushrooms and organ meat.
  • As you age, levels of ergothioneine decline in the body, potentially contributing to a decline in cellular, brain, heart, and muscle health.
  • Ergothioneine is absorbed in the small intestine and transported throughout the body via a specific transporter known as the Organic Cation Transporter 1 (OCTN1). This transporter is highly selective for ergothioneine, allowing it to enter cells efficiently.
  • Once inside the cells, ergothioneine primarily exerts its effects as a potent antioxidant. It works by donating electrons to neutralize harmful free radicals and reactive oxygen species (ROS) that are generated during normal cellular metabolism and in response to environmental stressors.
  • Administration of ergothioneine in animal studies has been shown to reduce oxidative stress, mediate inflammatory markers, and promote cellular, brain, and heart health.
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 30
Amount Per Serving %DV
L-Ergothioneine 25 mg †
† Daily Value (DV) not established
REV.08.25

  • OTHER INGREDIENTS: Hypromellose (capsule), rice flour.
  • SUGGESTED DAILY USE: Take (1) capsule per day, with or without food.
  • CAUTION: For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.
  • Unique Formulation. Compared to the majority of products on the market with lower doses, ProHealth's Ergothioneine contains a clinically effective dose of 25 mg of ergothioneine per serving.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.
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SKU: 77485590828

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4.8 ★★★★★
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C.J.
Chelsea, US
★★★★★ 4
Pretty Good... Not amazing.... But pretty good.
Format: Paperback
Before taking a stab at my first real story I have decided to read two books on the art of writing fiction; "Techniques of the Selling Writer" by Dwight Swain, and the book I am reviewing now, "Plot and Structure" by James Bell. While Swain's book was more of an all inclusive manual on writing interesting fiction, Bell's book is focused strictly on, as the name suggests, plot and structure. What this book is not... This is not a 'how to write a novel' book; if you are going to just read one book on writing a fiction novel then "Techniques of the Selling Writer" may be the more appropriate choice. If you are looking for a book that deals with anything outside of plot and structure, this book will be of no help there either. This book is designed to be supplemental to an already moderately educated reader. If you read Swain's book first, then you will instantly recognize the principles of this book. What this book is... This is a great book on, you guessed it, Plot and Structure. It's actually a fairly concentrated look into the subject. The chapters... Ch 1: What's a plot, anyway? Ch 2: Structure: What holds your plot together. Ch 3: How to explode with plot ideas. Ch 4: Beginning strong. Ch 5: Middles. Ch 6: Endings. Ch 7: Scenes. Ch 8: Complex Plots. Ch 9: The character arc in plot. Ch 10: Plotting Systems. Ch 11: Revising your plot. Ch 12: Plot Patterns. Ch 13: Common plot problems and cures. Ch 14: Tips and Tools for plot and structure. I found the specificity of this book very helpful with each principle being illustrated by a paragraph or so of a known author's work. Bell handpicks excerpts from authors varying from Dean Koontz to Herman Melville, brilliantly pulling text from these masters and showing us how they went about the relevant technique. This easy to read nature and well outlined subject matter means I will be using several of its chapters as a personal reference guide in the future. I'm certain it will keep me from making many of the mistakes beginning writers make and possibly save me weeks in rewrites. I will say this though... "Techniques of the Selling Writer" is a better book and covers plot quite well too; so if you are only going to read one book on writing, that is a damn good place to start. If you want to supplement that reading further, "Plot and Structure" comes highly recommended. [...]
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Reviewed in the United States on May 26, 2010
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fernando pedernera
Houston, US
★★★★★ 5
Have no fear!, or The writer's Victorinox.
Format: Kindle
You can't praise this book enough. There are a ton of how-to books out there, but this one really made a difference for me. Think of writing as a journey through the woods: You set up, you get in the muddle, and you come out (hopefully) on the other side. When doing this, we try to use as many tools and resources as we can to make it to the other side, but most of the time you fail (or tools fail on you) and you end up starving or being eaten by some wild animal in the muddle of the story. What James Scott Bell wants you to have in clear is that the most useful tool you can have out there is YOU. And all of his tips, advice and excercises are aimed to one thing and one thing only: how to unleash and harness the power of your story (and survive). It provides clear, straight-forward tools and tips, adressing many aspects of the writing process you won't find in many of them. It is a must-read for anyone interested in the study of plots and storytelling. Relevant examples that take in consideration a wide array of writer profiles, and Bell does not abuse with film examples (and most of the movies it references are also books i.e.: the maltesse falcon, the godfather, etc.). It contains useful excercises at the end of each chapter to help you put the tehcniques in practice and bring the best out of your learning experience. It really helped me overcome several issues I had with my novel-writing and opened my mind to a new scope on plot and str.. This is a wonderful book, written in the same gripping style that the author suggests to use, and with great success. I think this is a wonderful book because it does not give infalible advice. To me that is very important. Let me ilustrate how I felt by giving you the following example: (after developing content) -Regular book: so just do This (and fail, miserably). -Bell's book: Many writers had this problem before and by doing This you might also find a solution for it. In case That doesn't work, you could maybe try This, or come back at it again later on with a fresh view and give it another try.
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Reviewed in the United States on August 18, 2017
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Nancy C. Beck
Dallas, US
★★★★★ 5
Excellent resource
Format: Paperback
Two novel ideas ago, I had to put that one aside because I stuffed it to the point where the story made no sense. I intend to go back to it at some point, but for now, it's collecting dust. Also collecting dust is my more recent idea. I started with an outline (of sorts), wrote and rewrote it a few times...only to get stuck on Chapter 8 or so. I didn't know where to take the story. This one will probably never get resurrected...but you never know. Which leads me to one of the best things in this book: outlining with index cards. There's at least one other book touting this, but I'm sure there are others that do. What sets this one apart, in my mind, is his suggestions on how to set it up. This doesn't comprise a huge part of the book, but it made enough sense to me that I decided to give it a whirl. Almost 50,000 words later, I'm still chugging along, taking into mind his ideas (I'd never heard it put quite this way) about doorways of no return (more on that in a moment). Sure, I've made some changes, throwing out cards, rearranging cards, adding cards. That's the beauty of this system: it's not set in granite. If your muse takes you in a way that's different from what you originally wrote, go for it! Mr. Bell explains the doorways simply, at first, as transitions - from beginning to middle and then middle to ending. The first doorway gets your Main Character from beginning to middle; the idea is to create a scene where the MC is thrust into conflict in a way that keeps him/her there. With the second doorway (middle to ending), something has to happen to set up the final confrontation. It's usually a huge clue, a big piece of information, or a major crisis that sends the MC hurtling towards the conclusion. Mr. Bell explains these in greater detail, and I found his explanations quite understandable. But there's more to this book than that. Mr. Bell gets into how to come up with plot ideas, character arcs, revising, plot problems and cures, scenes, and tips and tools. I wasn't bothered by his reusing some of the same good writing examples, but it may make you cringe or roll your eyes. Other than that minor quibble, I think everything else about this book makes it shine as a writer's resource.
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Reviewed in the United States on December 1, 2006
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Verified Purchase
Corwin
New York, US
★★★★★ 5
Most Helpful Book I've Read on Plot and Structure
Format: Paperback
This is a well-organized, easy-to-read guide to techniques used to develop plots and sound story structure. It includes 14 chapters and two appendices. They cover such topics as what a plot is, how structure holds plot together, how to get ideas, and how to handle/interweave plot into all the levels of a novel (from whole sections such as the Beginning or middle of the work, down to the micro level of individual scenes). He includes discussion of different "plotting systems" (from writing by "the seat of your pants" to types/methods of creating outlines of various levels of "thoroughness" for those interested in mild outlining to someone with full-blown OCD). It discusses complex plots and sub plots, character arcs in relation to plot, common problems and solutions, revision, and more. Every chapter ends with a few exercises to reinforce the topic covered. The two appendices are a checklist for reminding you of major plot components as you write, and how to create "back cover" (aka the blurbs on the back of your book, or the summaries on the inside flap of dust jackets). As a writer, I am a "seat of the pants" guy, who's reluctantly recognized it isn't working for me (a major motivation for getting this book). Bell's discussion of different styles of outlining, though brief, gave me ideas of how to proceed. While I've often read books that include exercises, I confess to rarely doing them -- Bell is an exception (no, I didn't do *all* of them, but.... :) ). His text uses plenty of examples, drawn from movies and well-known novels. I've read other works on plot and structure (both general books and at least two dedicated to these topics), and have found this one to be by far the most readable, instructive, easy-to-digest, and *helpful.*
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 17, 2017
C
Verified Purchase
Cora L. Foerstner
Lowell, US
★★★★★ 5
I have a few instructional writing books I reread; this is one of them.
Format: Paperback
Plot & Structure: Techniques and Exercises for Crafting a Plot That Grips Readers from Start to Finish by James Scott Bell may be the best book for plotting and creating structure in fiction stories that I’ve read. I have a few instructional writing books I reread; this is one of them. Plot & Structure works for writers who don’t use outlines and for those who do. Throughout Bell acknowledges and addresses how his ideas about plot and structure can be used by all writers. This isn’t a “my way or the highway” kind of book. Bell gives practical advice for all writers. What’s so great about Plot & Structure? The biggest plus is Bell’s practical and down to earth strategies and clear explanations. Here are the other greats: Bell’s approach isn’t a how-to formula; it’s more of a guide. His genre is thrillers, but he addresses the needs of other genres as well as those of literary fiction. He provides many strategies writers can use to approach plot and structure; plus, he encourages readers to find their own way of working. The exercises at the end of the chapters are practical. If you try some of them, you’ll discover that they aren’t busywork but helpful approaches to solving writing issues. Unless you’re a pro with so many publications behind you that you don’t need help, this isn’t a book to read once and put away. It’s a book you’ll come back to and get more out of with a second or third reading. If you want a formula or step-by-step program, this isn’t a book for you. He gives choices so you can find you own style and way of working. Which is one of the things like I about the book. It’s like going to a writer buffet and choose the strategies that work for you. If you are someone who writes without an outline, you are going to be surprised because Bell doesn’t leave you out of any of the equations. He has strategies for all writers.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 13, 2014

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