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Description
GORASP2 Recombinant Rabbit mAb (S-2526-47)Product Specification Host Rabbit Antigen GORASP2 Synonyms Golgi reassembly stacking protein 2; GRS2; Golgi phosphoprotein 6 (GOLPH6); Golgi reassembly stacking protein of 55 kDa (GRASP55); p59; GOLPH6 Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession Q9H8Y8 Clone Number S 2526 47 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample U 87 MG, HeLa, HepG2, K562, mouse testis, rat
Product Specification
| Host | Rabbit |
| Antigen | GORASP2 |
| Synonyms | Golgi reassembly-stacking protein 2; GRS2; Golgi phosphoprotein 6 (GOLPH6); Golgi reassembly-stacking protein of 55 kDa (GRASP55); p59; GOLPH6 |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | Q9H8Y8 |
| Clone Number | S-2526-47 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | U-87 MG, HeLa, HepG2, K562, mouse testis, rat testis |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000-1:2000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
GORASP2 (also called GRASP55) is a peripheral membrane protein encoded by the GORASP2 gene, located on the medial-trans face of the Golgi apparatus, where it acts as a "molecular glue" by forming trans-oligomers through its conserved N-terminal GRASP domain to stack adjacent cisternae into the characteristic Golgi ribbon . In normal growth conditions it is O-GlcNAcylated, but upon glucose or energy starvation it is rapidly de-O-GlcNAcylated and a subpopulation relocates to the autophagosome–lysosome interface, where it tethers LC3-II on autophagosomes to LAMP2 on lysosomes, thereby facilitating autophagosome–lysosome fusion and promoting autophagosome maturation as an unconventional energy sensor.
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