CD117/c-Kit Fc Chimera Protein, Mouse
SKU: 47219130516

CD117/c-Kit Fc Chimera Protein, Mouse

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Description

CD117/c-Kit Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD117 antigen; CD117; ckit; c kit; EC 2. 7. 10; EC 2. 7. 10. 1; KIT; PBT; piebald trait; Proto oncogene c Kit; proto oncogene tyrosine protein kinase Kit; SCF R; SCFR; SCFRmast stem cell growth factor receptor; soluble KIT variant 1; Tyrosine protein kinase Kit; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein Accession P05532

Product Specification


Species Mouse
Synonyms CD117 antigen; CD117; ckit; c-kit; EC 2.7.10; EC 2.7.10.1; KIT; PBT; piebald trait; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCF R; SCFR; SCFRmast/stem cell growth factor receptor; soluble KIT variant 1; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Accession P05532-2
Amino Acid Sequence Ser25-Pro523, with C-terminal His
Expression System HEK293
Molecular Weight 95-120kDa (Reducing)
Purity >95% by SDS-PAGE & >95% by SEC-HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized Powder
Storage Buffer PBS, PH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference


1.Kimura, Y. et al. (2011) PLoS ONE 6:e26918. 2.Tallini, Y.N. et al. (2009) Proc. Natl. Acad. Sci. USA 106:1808. 3.Bashamboo, A. et al. (2006) J. Cell Sci. 119:3039. 4.Sun, L. et al. (2004) J. Clin. Invest. 113:1364.

Background

Stem Cell Factor Receptor (SCF R), also known as c-Kit and CD117, is a widely expressed 145 kDa receptor tyrosine kinase. It is the cellular homolog of the feline sarcoma virus protein, v-Kit. Binding of SCF R to SCF, also known as Steel Factor and Kit Ligand, promotes the survival, differentiation, and mobilization of progenitor cells in multiple lineages. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

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SKU: 47219130516

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4.2 ★★★★★
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Burtons
Birmingham, US
★★★★★ 5
Balls balls balls and more balls
Color: Mixed Color-20PK
A lot of balls for the price they bounce well and my dog likes squeaking them cuz he thinks he's talking to us. My sister's dog comes over and wants to pull the fuzz off the Rubber Ball and sometimes take the squeaker out of the ball. We like the variety of colors so we can keep track of which ball is where.
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Reviewed in the United States on March 29, 2026
J
Verified Purchase
jeremy
Birmingham, US
★★★★★ 5
Durable and relatively chew proof
Color: Mixed Color-20PK
We've tried a variety of square balls for our mini daschund because she loves to play with them. So far, these are the best we've purchased. They squeak well, but have the plastic squeaker opening covered by the colored cloth of the tennis ball, making the squeak less abrasive and preventing it dog from chewing of the squeaker.
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Reviewed in the United States on February 8, 2026
M
maskedgamer
Boise, US
★★★★★ 5
Thinks a fun little sniffy toy
Color: blue, Color: blue
My puppy seemed curious and didn’t mind playing with this sniffy toy. It’s large and well made and has plenty of title spots to hide stuff. I put kibble in it and my little puppy sniffed and googled a way. I guess this is great for keeping dogs busy and entertained. It’s a pretty cool little way to give dogs treats or snacks.
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Reviewed in the United States on March 7, 2026
K
Verified Purchase
Ken
West Palm Beach, US
★★★★★ 5
Tennis balls
Color: Squeaky-Multi Colors, Size: 2.5"(Medium)-12 Pack
Nice tennis balls, my dog loves them! Great value.
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Reviewed in the United States on May 25, 2026
L
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Lynn Dion
Massapequa, US
★★★★★ 5
Bright color and tough skin both great
Color: Regular-Orange, Size: 2.5"(Medium)-12 Pack
These tennis-style balls are, as promised, much tougher and thicker-skinned than an ordinary tennis ball, being made as a fetching ball for dogs. I bought them as foot covers for the legs of walkers used by the elderly, a very popular use. They work extremely well to protect rugs and flooring, and to make a quiet gliding cover, easier for seniors to move smoothly without snags. The usual tennis balls used for this purpose wear out pretty quickly, but this ball was made to be repeatedly fetched and gnawed on by your Rottweiler, so it's a big improvement. You will need a good cutting tool to score in the crosswise slits where you insert the walker leg; it's too tough for your household scissors, but that's just the point, right? It's tough. Very much recommended!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 8, 2024

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