CD30/TNFRSF8 Fc Chimera Protein, Mouse
SKU: 41839580047

CD30/TNFRSF8 Fc Chimera Protein, Mouse

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Description

CD30/TNFRSF8 Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD30; CD30KI 1; CD30L receptor; D1S166EKi 1; TNFRSF8 Accession Q60846 Amino Acid Sequence Phe19 Thr281, with C hIgG Fc Expression System HEK293 Molecular Weight 72 95kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, PH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid

Product Specification


Species Mouse
Synonyms CD30; CD30KI-1; CD30L receptor; D1S166EKi-1; TNFRSF8
Accession Q60846
Amino Acid Sequence Phe19-Thr281, with C-hIgG Fc
Expression System HEK293
Molecular Weight

72-95kDa (Reducing)

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Physical Appearance Lyophilized Powder
Storage Buffer PBS, 5% trehalose, PH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Oflzoglu E. et al. (2009) Adv. Exp. Med. Biol. 647:174
2. Kennedy, M.K. et al. (2006) Immunology 118:143.
3.Tarkowski, M. (2003) Curr. Opin. Hematol. 10:267.

Background

CD30, also known as Ki-1 antigen and TNFRSF8, is a 120 kDa type I transmembrane glycoprotein belonging to the TNF receptor superfamily. Mature mouse CD30 consists of a 264 amino acid (aa) extracellular domain (ECD) with three cysteine-rich repeats, a 27 aa transmembrane segment, and a 190 aa cytoplasmic domain. In contrast, human CD30 includes an additional 90 aa in the ECD and contains six cysteine-rich repeats. CD30 is normally expressed on antigen-stimulated Th cells and B cells. However, it is upregulated in Hodgkin’s disease (on Reed-Sternberg cells), other lymphomas, chronic inflammation, and autoimmunity. CD30 binds to CD30 Ligand/TNFSF8 which is expressed on activated Th cells, monocytes, granulocytes and medullary thymic epithelial cells. In B cells, CD30 ligation promotes cellular proliferation and antibody production in addition to the expression of CXCR4, CCL3,and CCL5. An 85 ‑ 90 kDa soluble form of CD30 is shed from the cell surface by TACE-mediated cleavage. Soluble CD30 retains the ability to bind CD30 Ligand and functions as an inhibitor of normal CD30 signaling.

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SKU: 41839580047

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Cheryl J
West Palm Beach, US
★★★★★ 5
Great story, beautiful pics
Format: Board book
Perfect book to go into a baby shower gift basket. Nice pictures and love the board book
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Reviewed in the United States on May 22, 2026
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Shanise
Carnegie, US
★★★★★ 5
Good quality book
Format: Board book
I wanted a book that can be a keep sake for my baby. This one is, it is well made and of good quality. I love the little story I read it to my newborn everyday. I love how calm the drawing and even the colors in this book are makes the images less overestimating.
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Reviewed in the United States on April 5, 2026
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Lady B
Pawtucket, US
★★★★★ 5
The Illustrations are Sweet, Storyline… Great!
Format: Board book
This book is sturdy and has a wonderful message. My grandchildren love it! If you are the one who presents 2 children in a classroom or other setting, most children will really love this book. The durability of the book is great. The illustrations are sweet. The review platform does not allow for me to enter an age span. It does not allow for me to enter multiple ages. It seems to force you to Select one age. I would say that having raised children of my own, I would start reading this book by one years old, but the average child I guess would best benefit with between ages like two and four. The book could be read up to people who are like six years old if they just love a sweet bedtime story.
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Reviewed in the United States on April 28, 2026
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Vickie D. Roderick
West Palm Beach, US
★★★★★ 5
Ms V
Format: Board book
Awesome book for my nephew. The book is good for a new reader to learn words from.
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Reviewed in the United States on May 29, 2026
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Gin
Chelsea, US
★★★★★ 5
Great quality
Format: Board book
Sweet little book . Color is vibrant and quality is extremely nice.
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Reviewed in the United States on May 29, 2026

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