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Description
PCSK9 His Tag Protein, HumanProduct Specification Species Human Synonyms Proprotein Convertase Subtilisin Kexin Type 9; Neural Apoptosis Regulated Convertase 1; NARC 1; Proprotein Convertase 9; PC9; Subtilisin Kexin Like Protease PC9; PCSK9; NARC1 Accession Q8NBP7 Amino Acid Sequence Gln31 Gln692, with C terminal His Expression System HEK293 Molecular Weight Theoretical: 72. 7kDa Actual: 65kDa Purity 95% by SDS PAGE&>95% by SEC HPLC Endotoxin <1EU g Tag His Tag Physical
Product Specification
| Species | Human |
| Synonyms | Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1 |
| Accession | Q8NBP7 |
| Amino Acid Sequence | Gln31-Gln692, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight |
Theoretical:72.7kDa Actual:65kDa
|
| Purity | ＞95% by SDS-PAGE&>95% by SEC-HPLC |
| Endotoxin | <1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer |
PBS, pH7.4.
|
| Reconstitution |
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
|
| Stability & Storage |
|
Background
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.
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4.6 ★★★★★
Based on 926 reviews
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Product Reviews
★★★★★ 5
Incredible quality, just buy the right size (I did not)
Color: A Silver, Size: 12 Ounces, Color: A Silver, Size: 12 Ounces
For anyone interested in this product, here’s a quick guide (from a coffee snob)
• 12oz (what I got, pictured) - fine for small drinks (standard mug) at home. one drink, and you never plan on using this for any larger drinks
• 20oz - the home kitchen sweet spot. if you’re filling a Stanley or Yeti traveler this is probably your size. One caveat, you’ll have no wiggle room and will be maxing your milk froth to the brim. if you like cappuccino’s get the 32oz.
• 32oz - this is what’s behind the counter at every coffee shop you’ve ever been to. if you’ve worked a bar shift at Starbucks you’ve held this pitcher a thousand times. If you like a lot of foam (cappuccinos) i would suggest anyone serious about at home use to get this one.
I’ve worked in coffee shops since I was like 16 and I still ordered the 12oz like a complete idiot. I posted comparison photos if you want a good laugh. The pitcher is smaller than a regular coffee mug. Not a travel mug, not a big mug, just a normal everyday mug. Bigger than the pitcher. I measured nothing and paid the price.
Returning it and ordering the 32oz of the same exact pitcher so that should tell you the quality is legit. Feels exactly like what we used behind the bar, well made, solid, nothing cheap about it. Just bought the wrong size.
For anyone also about to make my mistake: the 12oz works if you’re making one small drink at home and that’s it. The 20oz is probably the right call for most people, fills a Stanley or Yeti no problem. The 32oz is the coffee shop size, if you’ve ever worked a bar at Starbucks or anywhere else you’ve used that size a thousand times and it’ll feel right immediately.
Great pitcher. Wrong size. My fault entirely.
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Reviewed in the United States on May 10, 2026
★★★★★ 5
Excellent in every respect, regardless of price. Just get the right size for your needs.
Color: A Silver, Size: 12 Ounces
Over time I've accumulated several milk steaming pitchers, a few of which were 3 or 4x the price, and yet I keep coming back to this one. The build quality is surprisingly high, the volume markings are very clearly etched on the inside and easy to read, it has a nice no-drip spout for pouring, and it still looks as good as new after daily use; No sign of wear and tear or staining on the metal even with high heat milk steaming. This is one of those rare low price/high quality products I only rarely run across.
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Reviewed in the United States on June 8, 2026
★★★★★ 5
Lovely milk pitcher
Color: A Silver, Size: 12 Ounces, Color: A Silver, Size: 12 Ounces
This milk pitcher is so durable and light weight. Its great value for money and feels expensive. Its easy to use and also easy to clean. It pours very well and fits perfectly on my coffee machine.
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Reviewed in the United States on March 2, 2026
★★★★★ 5
Great for single drinks, high quality
Color: A Silver, Size: 12 Ounces
High quality milk frother pitcher. A bit smaller than I expected but great for making single size drinks. High quality stainless that holds heat well and is easy to clean. Great value for the price for making quick single drinks with your espresso maker
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Reviewed in the United States on January 4, 2026
★★★★★ 4
Great Quality Frothing Pitcher for Coffee Lovers!
Color: A Silver, Size: 12 Ounces
This stainless steel milk frothing pitcher is a great addition for anyone who enjoys making lattes, cappuccinos, or homemade coffee drinks. The pitcher feels sturdy and well-made, and the measurement markings inside are super helpful for getting the right amount every time. The pouring spout gives good control for latte art, and the included art pen is a nice bonus for beginners.
The handle is comfortable to hold, and the stainless steel material cleans easily after use. It also works well for steaming milk, mixing drinks, or even small kitchen tasks beyond coffee.
✅ Pros:
* Durable stainless steel construction
* Easy-to-read measurement markings
* Great pouring spout for latte art
* Comfortable handle grip
* Includes latte art pen
* Easy to clean
❌ Cons:
* Smaller sizes may not hold enough for multiple drinks
* Metal exterior can get hot when steaming milk
* Latte art takes practice for beginners
Overall, this is an affordable and practical frothing pitcher that works great for home baristas and everyday coffee lovers alike!
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Reviewed in the United States on May 20, 2026