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Description
CD300b/LMIR5/CD300LB Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD300b Protein, Human; CLM 7 Protein, Human; CLM7 Protein, Human; CMRF35 A2 Protein, Human; IREM 3 Protein, Human; IREM3 Protein, Human; TREM 5 Protein, Human; TREM5 Protein, Human Accession Q3U497 Amino Acid Sequence Ile18 Tyr157, with C hIgG Fc Expression System HEK293 Molecular Weight 52 64kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Physical Appearance Lyophilized
Product Specification
| Species | Mouse |
| Synonyms | CD300b Protein, Human; CLM-7 Protein, Human; CLM7 Protein, Human; CMRF35-A2 Protein, Human; IREM-3 Protein, Human; IREM3 Protein, Human; TREM-5 Protein, Human; TREM5 Protein, Human |
| Accession | Q3U497 |
| Amino Acid Sequence | Ile18-Tyr157, with C-hIgG Fc |
| Expression System | HEK293 |
| Molecular Weight | 52-64kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Journal List Cell Death Differ v.21(11); 2014 Nov PMC4211373. |
Background
The CD300 receptor family members are a group of molecules that modulate a variety of immune cell processes. The CD300 receptor family consists of members with activating and inhibitory capabilities mainly expressed on the surface of immune cells. LMIR5, also known as CD300b, CD300LB, CLM-7, and IREM-3, is a glycoprotein member of the immunoglobulin superfamily. Human LMIR5 consists of a 134 amino acid (aa) extracellular domain (ECD) with one Ig-like V-type domain, a 21 amino acid (aa) transmembrane segment, and a 29 aa cytoplasmic domain. Studies have shown that CD300b recognizes PS as a ligand and regulates phagocytosis of apoptotic cells through DAP12 signaling pathway.
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