IL-28A/IFN-λ2 Protein, Mouse
SKU: 1529440896

IL-28A/IFN-λ2 Protein, Mouse

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Description

IL-28A/IFN-λ2 Protein, MouseProduct Specification Species Mouse Synonyms Interferon lambda 2; IFN lambda 2; Interleukin 28A; IL 28A; Accession Q4VK74 Amino Acid Sequence Asp20 Val193 Expression System E. coli Molecular Weight 20 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris, 150mM NaCl, pH8. 0 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size

Product Specification


Species Mouse
Synonyms Interferon lambda-2; IFN-lambda-2; Interleukin-28A; IL-28A;
Accession Q4VK74
Amino Acid Sequence

Asp20-Val193

Expression System E.coli
Molecular Weight

20 kDa (Reducing)

Purity >95% by SDS-PAGE and HPLC.
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag No Tag
Physical Appearance Lyophilized Powder
Storage Buffer 20mM Tris, 150mM NaCl, pH8.0
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

Nat Immunol. 2003 Jan;4(1):63-8.

Background

Interferon lambda 2 (IFN-λ2), also known as IL-28A, is a member of the type III interferon family, which also includes IFN-λ1 and IFN-λ3. IFN-λ2 plays a crucial role in the innate immune response to viral infections and has been shown to exhibit antiviral activity against a variety of viruses, including hepatitis C virus, influenza virus, and others. It signals through the IFN-λ receptor complex, leading to the activation of JAK-STAT signaling pathways and the induction of interferon-stimulated genes (ISGs) that contribute to the antiviral defense mechanisms. IFN-λ2 is primarily produced by immune cells, such as dendritic cells and macrophages, in response to viral stimuli and functions as a key mediator of the host's defense against viral pathogens.

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SKU: 1529440896

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