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Description
Serpin D1 His Tag Protein,MouseProduct Specification Species Mouse Synonyms Heparin cofactor 2; Heparin cofactor II; HC II; Protease inhibitor leuserpin 2; Serpin D1 Accession P49182 Expression System HEK293 Molecular Weight 53. 1 KDa Purity 95% by SDS PAGE Endotoxin <1EU g Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer 50mM Tris HCl, 150mM NaCl, 5% Mannitol, 0. 06% Tween80, pH8. 0. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or
Product Specification
| Species | Mouse |
| Synonyms | Heparin cofactor 2; Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; Serpin D1 |
| Accession | P49182 |
| Expression System | HEK293 |
| Molecular Weight | 53.1 KDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 50mM Tris-HCl, 150mM NaCl, 5% Mannitol, 0.06% Tween80, pH8.0. |
| Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Stability & Storage |
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Background
SerpinD1, also known as heparin cofactor II(HC-II), is a member of Serpin superfamily of the serine proteinase inhibitors. It is a single chain glycoprotein with a size of 66.5 kDa and is secreted from hepatocytes. HC-II acts as a thrombin inhibitor in the coagulation cascade, in a glycosaminoglycan-dependent pathway using the release of a sequestered hirudin-like N-terminal tail for interaction with thrombin. This serpin belongs to multiple member group V2 of vertebrate serpin classification. It has been suggested that HC-II is a predictor of decreased atherosclerosis in the elderly and protective against atherosclerosis in mice. HCII can used as a predictive biomarker and therapeutic target for atherosclerosis.
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